Alpha-Lipoic Acid: Therapeutic Potential in Diabetic Neuropathies
نویسندگان
چکیده
منابع مشابه
Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment.
INTRODUCTION Diabetes mellitus is a metabolic, chronic and incurable disease which reduces span and quality of life. Over 50% of diabetic patients have clinical manifestations of diabetic neuropathy. AIM To show a positive influence of alpha lipoic acid on clinically manifested diabetic neuropathy symptoms as well as the effect of alpha lipoic acid in patients glycaemic control. MATERIAL AN...
متن کاملLipoic acid - biological activity and therapeutic potential.
α-Lipoic acid (LA; 5-(1,2-dithiolan-3-yl)pentanoic acid) was originally isolated from bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was found that LA is not a vitamin and is synthesized by plants and animals. LA is covalently bound to the ε-amino group of lysine residues and functions as a cofactor for mitochondrial enzymes by catalyzing the oxidative d...
متن کاملAlpha-Lipoic Acid
OBJECTIVE: To evaluate the efficacy and safety of oral treatment with the antioxidant alpha-lipoic acid (ALA) in NIDDM patients with cardiac autonomic neuropathy (CAN), assessed by heart rate variability (HRV). RESEARCH DESIGN AND METHODS: In a randomized, double-blind placebo-controlled multicenter trial (Deutsche Kardiale Autonome Neuropathie [DEKAN] Study), NIDDM patients with reduced HRV we...
متن کاملAlpha-lipoic acid for the prevention of diabetic macular edema.
INTRODUCTION To evaluate the effect of α-lipoic acid (ALA) on the occurrence of diabetic macular edema. METHODS Randomized, double-blind, placebo-controlled, multicenter, multinational study. Patients were randomized to the treatment group with 600 mg ALA per day or the placebo group. Every 6 months stereo fundus photographs, HbA1c levels, and an ophthalmological examination were documented. ...
متن کاملAlpha Lipoic Acid
Alpha lipoic acid, or just lipoic acid (LA), is a unique and potent antioxidant. It can deliver antioxidant activity in both fatand water-soluble mediums, and it is capable of having an antioxidant effect in both its oxidized (LA) and reduced (DHLA [dihydrolipoic acid]) forms (Goraca et al., 2011). This effectively allows LA to deliver its antioxidant effect to any cell or tissue type, as well ...
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ژورنال
عنوان ژورنال: Current Research in Diabetes & Obesity Journal
سال: 2018
ISSN: 2476-1435
DOI: 10.19080/crdoj.2018.07.555713